OMOMIND is a food supplement based on Homotaurine, Betaine, Vitamin B6, Quatrefolic, Vitamin B12 and Vitamin D3. Useful in slowing down cognitive decline and the early stages of dementia..
Mild cognitive decline or mild cognitive impairment (MCI)
Mild cognitive decline is a transitional state between physiological aging and the more severe form of dementia.
Symptoms include memory lapses, mild language and operating functions impairment without affecting normal daily activities.
MCI conversion rate to dementia is about 20% per year.
MAJOR NEUROCOGNITIVE DISORDER OR DEMENTIA
Major neurocognitive disorder is a set of disorders that worsen over time (chronic-degenerative) and show up with particular symptoms. Are impaired:
- language
- memory
- learning
- orientation
- understanding
- behavior
- The ability of calculation and judgment
These symptoms significantly interfere with a person’s ability to maintain daily and social routines. Major neurocognitive disorder is progressive and is classified as following: mild, moderate and severe dementia based on the severity of symptoms. The patient may behave unusually. Eat, drink and stay active become more difficult resulting in muscle weakness and weight loss.
The origins of Alzheimer’s disease
Mechanisms underlying the disease
OMOMIND
WHAT IS HOMOTAURINE (TRAMIPROSATE)?
It is a low molecular weight sulfonate compound extracted from different species of red seaweed following a chemical synthesis in order to be introduce to the pharmaceutical market. Homotaurine plays a key role: it can slow down cognitive decline, improve memory, and protect the brain from aging and oxidative stress. It is the only natural substance to have reached a phase 3 clinical trial for its positive effects on Alzheimer’s patients. Homotaurine does not interfere with Cytochrome P 450 and is hepatically cleared. It’s exert a neuroprotective effect related to inhibition of excitotoxicity, neuroinflammation, and oxidative stress on one hand and it is involved in the regulation of gene expression, energy metabolism, and proper protein folding on the other hand. Homotaurine, by binding the Aβ peptide through its sulfonate end, has been shown to block the molecular transition of the peptide from a “random coil” structure to a β-sheet structure and its subsequent oligomerization with the formation of neurotoxic compounds. There are no adverse effects and it is safe and well tolerated.
RISK FACTORS
HIGH HOMOCYSTEINE LEVELS AND BRAIN DAMAGE
- Progression of cognitive decline in paraphysiological aging
- Conversion of cognitive impairment to dementia
- Increases cognitive decline in patients with Alzheimer’s disease
- Triggers excitotoxicity
- Promotes the β- amyloid accumulation
- Enanches the rate of brain atrophy
VITAMIN D DEFICIENCY
The Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS) claims that 80% of the population in Italy is vitamin D deficency that would increase with advancing age affecting almost the entire elderly population. Vitamin D deficiency is a risk factor for the development of cognitive decline and dementia in the elderly people. Elderly subjects with reduced vitamin D levels have a 2-4 times higher risk of developing cognitive impairment. The vitamin D receptor is particularly expressed in brain areas most affected of dementia. Vitamin D reduces the neuroinflammation and counteracts β-amyloid neurotoxic action by limiting its accumulation and elimination. The recommended vitamin D dose ranges from 400 to 1000 IU per day. OMOMIND contains 25µg of cholecalciferol (vitamin D3), which corresponds to 1000 units.
It is recommended to take one sachet daily, after meals, with a glasses of water.
