KAUMA

KAUMA is the natural alternative to benzodiazepines.

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KAUMA is a natural product useful to counteract ANXIETY disorder.

KAUMA is a food supplement containing extracts of Passionflower, Eschscholzia, Skullcap. The active ingredients have the ability to bind GABA-A receptor site enhancing its anxiolytic properties and showing an efficacy similar to benzodiazepines without their typical side effects.

Kauma tablet bilayer contains.

Eschscholtzia Eschscholtzia californica Cham, dry extract titrated to 0.2-0.24% total alkaloids as protropin. Eschscholzia belongs to the papaveraceae family.
Passionflower Passiflora incarnata L, dry extract titrated to 4% total flavonoids as vitexin.
Scutellaria Scutellaria baicalensis Georgi, dry extract titrated to 95% baicalin.

REQUEST THE ENTIRE NUTRITIONAL INFORMATION TABLE

PASSIONFLOWER

Passionflower extract contains flavonoid glycosides (VITEXIN) having anxiolytic properties and a benzodiazepine-like action,able to positively modulate gabaergic transmission. It is indicated for the treatment of sleep disturbances related to restlessness, anxiety, and stress, by promoting a peaceful sleep without creating numbness the next morning.

Passiflora Incarnata is a climbing, herbaceous, perennial plant native to North America, Central America, and South America. The plant is cultivated and harvested to obtain the dried aerial parts for medicinal use (herbal substance).

The main plant parts are:

Flavonoids (25%) : chrysin, vitexin, isovitexin
Indole alkaloids: armalin,armalol, armane
Fatty acids: linoleic, linolenic, myristic, palmitic

Eschscholzia californica

ESCHSCHOLTZIA californica extract contains alkaloids (PROTROPINE) that act on the CNS with specific sedative and anxiolytic properties.

It promotes falling asleep without numbness relative to hypnotic drugs .

Plant belongs to papaveraceae genus native to North America
Contains alkaloids and flavonoids with sedative effect
Used for centuries by North American Indians as a natural remedy for stress and headaches.

SKULLCAP

The SKULLCAP anxiolytic action is mainly due to the flavonoids (BAICALINE and BAICALEINE), that have affinity for GABA-A receptor (as synthetic benzodiazepines) by stimulating the synthesis and release of the neurotransmitter GABA and inhibiting the enzyme GABA-transaminase, responsible for GABA catabolism.

The substances within KAUMA are DRY EXTRACTS STANDARDIZED AND TITRATED into secondary metabolites that have pharmacological activity

DRY EXTRACT:

product obtained as a result of total extraction solvent evaporation (e.g., spray dry). The extract/drug ratio is 1/4, i.e. 4 kilograms of drug (plant or plant part) are used in order to obtain 1 kg of extract.

STANDARDIZED DRY EXTRACT:

extract whose the reproducibility of extraction and content is always the same and then standardized (extract/drug ratio 1 / 4 , is constantly guaranteed)

STANDARDIZED AND TITRATED DRY EXTRACT:

Following extraction, the presence (standard) of one or more secondary metabolites is also guaranteed, it is known as standardized and titrated dry extract. The dry extract is then defined since an appropriate amount of active ingredient is certified and guaranteed.

TABLE OF SECONDARY METABOLITES:

Substance	Chemistry	Ecological role	Plant	Physiological action (man)
POLYPHENOLS	Carbohydrate derivatives			Various properties
Vitexin	Flavonoid	Pigment	Passiflora incarnata L, aerial parts with flowers	Relax (sleep in case of stress, sleep). Mental well-being
Baicalin	Flavonoid	Pigment	Scutellaria baicalensis Georgi, root	Relax
ALCALOIDS	Amino acid derivatives	Defense mechanism		Actions on the CNS
Protopin			Scutellaria baicalensis Georgi, root	Sleep, relax; in case of stress

IN-DEPTH ANALYSIS

Kauma is a double-layer tablet

unconventional release

The FAST-RETARD formulation allows the release of the correct ingredient amount in each site, at a specific speed and time.

This allow a better use of the active ingredients with an improvement of patient compliance

FAST LAYER
RETARD LAYER.

FAST LAYER

It represents the part of the tablet that, once it reaches the gastro-intestinal tract, completely and quickly disintegrates due to the polymers it contains, which, by attracting water, swell and dissolve quickly (< 5 minutes).

CONTAINS:

PASSIFLOWER (e.s. tit. 4% in vitexin)
CALIFORNIA POPPY (d.e. tit. 0.2-0.24% in protropin)

for a rapid onset of anxiolytic action and to act on initial insomnia, reducing the risk of daytime sleepiness . It makes the active ingredient available for a faster absorption than conventional forms.

INCREASED ABSORPTION RATE – INCREASED BIOAVAILABILITY

RETARD LAYER.

It represents the part of the tablet (matrix layer) that does not disintegrate once reaches the gastro-intestinal tract but consumes slowly along the intestinal tract; this allows a delayed and prolonged release of the active ingredient (over 4 hours).

CONTAINS:

SKULLCAP (e.s. tit. 95% baicalin)

for alasting anxiolytic action

BETTER ACTIVE INGREDIENTS BIOAVAILABILITY
BETTER THERAPEUTIC EFFICACY
REDUCTION OF ADMINISTERED DOSE
LOWER INCIDENCE OF SIDE EFFECTS
BETTER USE OF ACTIVE INGREDIENTS WITH A BETTER PATIENT COMPLIANCE
RELEASE OF THE CORRECT INGREDIENT AMOUNT IN EACH SITE, AT A SPECIFIC SPEED AND TIME

EFFECTIVE

NO ADVERSE EVENTS

NO IMPACT ON JOB PERFORMANCE

AWAKENING DEVOID OF NUMBNESS TYPICAL OF HYPNOINDUCERS