{"id":7641,"date":"2024-05-16T09:02:34","date_gmt":"2024-05-16T09:02:34","guid":{"rendered":"https:\/\/www.arcapharma.com\/web\/?p=7641"},"modified":"2024-05-17T09:32:59","modified_gmt":"2024-05-17T09:32:59","slug":"ehi-tu-alzheimer-chi-sei","status":"publish","type":"post","link":"https:\/\/www.arcapharma.com\/web\/2024\/05\/16\/ehi-tu-alzheimer-chi-sei\/","title":{"rendered":"Ehi tu, Alzheimer&#8230;. Chi sei?"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"--awb-bg-color:#ffffff;--awb-bg-color-hover:#ffffff;--awb-bg-size:cover;--awb-border-color:#25afb4;--awb-border-bottom:0;--awb-border-style:solid;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-1\"><h1 class=\"p1\" style=\"text-align: left;\">Ehi tu, Alzheimer&#8230;. Chi sei?<\/h1>\n<h4>Il lato \u201cnascosto\u201d della malattia<\/h4>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:10px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-equal-height-columns\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-margin-top:30px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_4 1_4 fusion-one-fourth fusion-column-first\" style=\"--awb-bg-size:cover;width:25%;width:calc(25% - ( ( 4% + 4% ) * 0.25 ) );margin-right: 4%;\" data-motion-effects=\"[{&quot;type&quot;:&quot;&quot;,&quot;scroll_type&quot;:&quot;transition&quot;,&quot;scroll_direction&quot;:&quot;up&quot;,&quot;transition_speed&quot;:&quot;1&quot;,&quot;fade_type&quot;:&quot;in&quot;,&quot;scale_type&quot;:&quot;up&quot;,&quot;initial_scale&quot;:&quot;1&quot;,&quot;max_scale&quot;:&quot;1.5&quot;,&quot;min_scale&quot;:&quot;0.5&quot;,&quot;initial_rotate&quot;:&quot;0&quot;,&quot;end_rotate&quot;:&quot;30&quot;,&quot;initial_blur&quot;:&quot;0&quot;,&quot;end_blur&quot;:&quot;3&quot;,&quot;start_element&quot;:&quot;top&quot;,&quot;start_viewport&quot;:&quot;bottom&quot;,&quot;end_element&quot;:&quot;bottom&quot;,&quot;end_viewport&quot;:&quot;top&quot;,&quot;mouse_effect&quot;:&quot;track&quot;,&quot;mouse_effect_direction&quot;:&quot;opposite&quot;,&quot;mouse_effect_speed&quot;:&quot;2&quot;,&quot;infinite_animation&quot;:&quot;float&quot;,&quot;infinite_animation_speed&quot;:&quot;2&quot;}]\" data-scroll-devices=\"small-visibility,medium-visibility,large-visibility\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-column-content-centered\"><div class=\"fusion-column-content\"><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_2 1_2 fusion-one-half\" style=\"--awb-bg-size:cover;width:50%;width:calc(50% - ( ( 4% + 4% ) * 0.5 ) );margin-right: 4%;\" data-motion-effects=\"[{&quot;type&quot;:&quot;&quot;,&quot;scroll_type&quot;:&quot;transition&quot;,&quot;scroll_direction&quot;:&quot;up&quot;,&quot;transition_speed&quot;:&quot;1&quot;,&quot;fade_type&quot;:&quot;in&quot;,&quot;scale_type&quot;:&quot;up&quot;,&quot;initial_scale&quot;:&quot;1&quot;,&quot;max_scale&quot;:&quot;1.5&quot;,&quot;min_scale&quot;:&quot;0.5&quot;,&quot;initial_rotate&quot;:&quot;0&quot;,&quot;end_rotate&quot;:&quot;30&quot;,&quot;initial_blur&quot;:&quot;0&quot;,&quot;end_blur&quot;:&quot;3&quot;,&quot;start_element&quot;:&quot;top&quot;,&quot;start_viewport&quot;:&quot;bottom&quot;,&quot;end_element&quot;:&quot;bottom&quot;,&quot;end_viewport&quot;:&quot;top&quot;,&quot;mouse_effect&quot;:&quot;track&quot;,&quot;mouse_effect_direction&quot;:&quot;opposite&quot;,&quot;mouse_effect_speed&quot;:&quot;2&quot;,&quot;infinite_animation&quot;:&quot;float&quot;,&quot;infinite_animation_speed&quot;:&quot;2&quot;}]\" data-scroll-devices=\"small-visibility,medium-visibility,large-visibility\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-column-content-centered\"><div class=\"fusion-column-content\"><div class=\"fusion-video fusion-selfhosted-video\" style=\"max-width:100%;\"><div class=\"video-wrapper\"><video playsinline=\"true\" width=\"100%\" style=\"object-fit: cover;\" autoplay=\"true\" muted=\"true\" preload=\"auto\" controls=\"1\"><source src=\"https:\/\/www.arcapharma.com\/web\/wp-content\/uploads\/2024\/05\/VIDEO-DEMENZA-SOTTOTITOLI-ITALIANO-1.mp4\" type=\"video\/mp4\">Sorry, your browser doesn&#039;t support embedded videos.<\/video><\/div><\/div><div class=\"fusion-text fusion-text-2\"><p style=\"text-align: center;\">Le origini dell&#8217;Alzheimer<\/p>\n<\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_4 1_4 fusion-one-fourth fusion-column-last\" style=\"--awb-bg-size:cover;width:25%;width:calc(25% - ( ( 4% + 4% ) * 0.25 ) );\" data-motion-effects=\"[{&quot;type&quot;:&quot;&quot;,&quot;scroll_type&quot;:&quot;transition&quot;,&quot;scroll_direction&quot;:&quot;up&quot;,&quot;transition_speed&quot;:&quot;1&quot;,&quot;fade_type&quot;:&quot;in&quot;,&quot;scale_type&quot;:&quot;up&quot;,&quot;initial_scale&quot;:&quot;1&quot;,&quot;max_scale&quot;:&quot;1.5&quot;,&quot;min_scale&quot;:&quot;0.5&quot;,&quot;initial_rotate&quot;:&quot;0&quot;,&quot;end_rotate&quot;:&quot;30&quot;,&quot;initial_blur&quot;:&quot;0&quot;,&quot;end_blur&quot;:&quot;3&quot;,&quot;start_element&quot;:&quot;top&quot;,&quot;start_viewport&quot;:&quot;bottom&quot;,&quot;end_element&quot;:&quot;bottom&quot;,&quot;end_viewport&quot;:&quot;top&quot;,&quot;mouse_effect&quot;:&quot;track&quot;,&quot;mouse_effect_direction&quot;:&quot;opposite&quot;,&quot;mouse_effect_speed&quot;:&quot;2&quot;,&quot;infinite_animation&quot;:&quot;float&quot;,&quot;infinite_animation_speed&quot;:&quot;2&quot;}]\" data-scroll-devices=\"small-visibility,medium-visibility,large-visibility\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-column-content-centered\"><div class=\"fusion-column-content\"><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"--awb-bg-color:#ffffff;--awb-bg-color-hover:#ffffff;--awb-bg-size:cover;--awb-border-color:#25afb4;--awb-border-bottom:0;--awb-border-style:solid;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-3\"><p><strong>Cos\u2019\u00e8 la malattia di Alzheimer<\/strong><\/p>\n<p>La malattia di Alzheimer \u00e8 una patologia neurodegenerativa a decorso cronico e progressivo che determina alterazioni a carico della memoria, del comportamento, della capacit\u00e0 di pensiero e di svolgimento dei compiti pi\u00f9 semplici.<\/p>\n<p>Rappresenta la forma pi\u00f9 comune di demenza nella popolazione anziana dei paesi ad alto reddito: si stima ne siano colpiti circa 55 milioni di persone, un valore che si prevede aumenter\u00e0 a 82 milioni entro il 2030 fino a raggiungere 152 milioni entro il 2050 [1].<\/p>\n<p>L\u2019esordio di questa patologia \u00e8 raro prima dei 65 anni mentre si accentua con l\u2019avanzare dell\u2019et\u00e0. A livello mondiale, l\u2019OMS (Organizzazione Mondiale della Sanit\u00e0) afferma che la malattia di Alzheimer e le altre forme di demenza rappresentano la settima causa di morte a livello mondiale. In Italia circa 1 milione di persone sono affette da demenza e di questi 600 mila soffrono di Alzheimer.<\/p>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-4\"><p><strong>Le &#8220;4 A&#8221; dell&#8217;Alzheimer<\/strong><\/p>\n<p>Sulla base dei principali sintomi, l\u2019Alzheimer pu\u00f2 essere definito come \u201cmalattia delle 4 A\u201d. Le A rappresentano quanto segue: AMNESIA (perdita significativa di memoria), AFASIA (incapacit\u00e0 di formulare e comprendere messaggi di tipo verbale e scritto), AGNOSIA (incapacit\u00e0 di riconoscere persone, oggetti e luoghi) e APRASSIA (incapacit\u00e0 di compiere semplici movimenti volontari).<\/p>\n<p>Le persone che manifestano la malattia di Alzheimer hanno spesso difficolt\u00e0 a svolgere le attivit\u00e0 quotidiane come guidare un&#8217;auto, cucinare un pasto o pagare le bollette; possono fare pi\u00f9 volte la stessa domanda, perdersi facilmente e perdere oggetti. Al progredire della patologia, alcuni pazienti possono manifestare atteggiamenti aggressivi e violenti.<\/p>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-5\"><p><strong>Cause dell\u2019Alzheimer<\/strong><\/p>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-6\"><p>La patologia di Alzheimer prende il nome dal neurologo tedesco Alois Alzheimer che nel 1906 diagnostic\u00f2 la malattia ad una sua connazionale di 51 anni che manifestava perdita di memoria a breve termine, problemi di linguaggio e di comportamento. Da un\u2019analisi cerebrale post-mortem, il neurologo not\u00f2 la presenza di depositi anomali di proteine (ora conosciuti come placche amiloidi e grovigli neurofibrillari della proteina TAU) accompagnati da un\u2019evidente atrofia della corteccia. La presenza di questi depositi proteici e la perdita di connessioni tra le cellule nervose (neuroni) sono ad oggi considerati le cause principali alla base dello sviluppo della patologia.<\/p>\n<p>Al momento gli esperti ritengono che le cause della malattia non siano del tutto chiare e che all\u2019origine della stessa ci sia una combinazione di vari fattori: familiarit\u00e0 genetica, fattori ambientali e stile di vita. Sulla base delle attuali conoscenze scientifiche, questo insieme di fattori sembrerebbe alterare la conformazione di alcune proteine cerebrali determinando effetti tossici sul cervello stesso.<\/p>\n<p>L\u2019ipotesi pi\u00f9 accreditata sembra coinvolgere il metabolismo della proteina precursore della \u03b2-amiloide (APP) che per ragioni ancora sconosciute porta alla formazione e all\u2019accumulo, a livello cerebrale, di una sostanza neurotossica (il peptide \u03b2-amiloide) con conseguente morte neuronale progressiva.<\/p>\n<p>Una seconda ipotesi attribuisce l\u2019esordio precoce della malattia (circa il 13 % dei casi) a mutazioni genetiche ereditarie. L\u2019insorgenza precoce (prima dei 40 anni) \u00e8 legata a mutazioni geniche a carico delle seguenti proteine: presenilina 1, presenilina 2, APP e apolipoproteina E [2].<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-4 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-margin-top:30px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-5 fusion_builder_column_1_4 1_4 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:25%;--awb-margin-top-large:0px;--awb-spacing-right-large:7.68%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:7.68%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-6 fusion_builder_column_1_2 1_2 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:3.84%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:3.84%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-video fusion-selfhosted-video\" style=\"max-width:100%;\"><div class=\"video-wrapper\"><video playsinline=\"true\" width=\"100%\" style=\"object-fit: cover;\" muted=\"true\" preload=\"auto\" controls=\"1\"><source src=\"https:\/\/www.arcapharma.com\/web\/wp-content\/uploads\/2024\/05\/Senza-titolo.mp4\" type=\"video\/mp4\">Sorry, your browser doesn&#039;t support embedded videos.<\/video><\/div><\/div><div class=\"fusion-text fusion-text-7\"><p style=\"text-align: center;\">Meccanismi alla base della malattia<\/p>\n<\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-7 fusion_builder_column_1_4 1_4 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:25%;--awb-margin-top-large:0px;--awb-spacing-right-large:7.68%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:7.68%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-5 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-8 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-8\"><p><strong>Fattori di rischio<\/strong><\/p>\n<p>Gli scienziati stanno ancora investigando cosa espone alcuni pazienti ad un rischio maggiore di sviluppare la malattia rispetto ad altri. Sebbene si conoscano alcuni dei fattori che influenzano l\u2019esordio della patologia, probabilmente ne esistono altri che non sono stati ancora identificati. Tra le condizioni di rischio pi\u00f9 conosciute ritroviamo: et\u00e0 avanzata (dopo i 65 anni la probabilit\u00e0 di sviluppo della patologia raddoppia ogni 5 anni), familiarit\u00e0 e predisposizione genetica (il rischio \u00e8 maggiore quando un parente di primo grado \u00e8 affetto dalla medesima malattia), sesso (le donne hanno una maggiore probabilit\u00e0, dovuta a fattori ormonali, di sviluppare la patologia) e stile di vita (sedentariet\u00e0, sindrome metabolica e fumo) [3].<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-9\"><p><strong>Prevenzione e Diagnosi<\/strong><\/p>\n<p>Anche se al giorno d\u2019oggi non esiste una misura preventiva nei confronti dello sviluppo della patologia, alcune ricerche suggeriscono che certe abitudini possano aiutare a prevenirla. Tali abitudini comprendono: costante attivit\u00e0 fisica ed appropriata stimolazione cognitiva, controllo periodico della pressione sanguigna, dei livelli di glicemia e colesterolo. Insieme queste strategie potrebbero apportare un miglioramento del benessere cerebrale e cognitivo.<\/p>\n<p>Per diagnosticare in maniera adeguata la malattia di Alzheimer, il paziente viene sottoposto a test neuropsicologici ed esami cerebrali specifici quali la RMN (Risonanza Magnetica Nucleare) e la PET (Tomografia a emissione di positroni) [4].<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-10\"><p><strong>SAGE test<\/strong><\/p>\n<p>Una diagnosi precoce dei primi segni di demenza renderebbe possibili interventi pi\u00f9 rapidi ed efficaci. A tal proposito, l\u2019universit\u00e0 dell\u2018Ohio, ha realizzato un test cognitivo geriatrico autosomministrato conosciuto come \u201cSAGE test\u201d. Sottoporsi periodicamente al test aiuter\u00e0 il proprio medico ad individuare prontamente i primi sintomi ed intervenire tempestivamente con le terapie adeguate [5].<\/p>\n<p>Esistono 4 versioni del test SAGE. Le domande su ciascuna versione sono leggermente diverse. Non importa quale versione si sceglie, poich\u00e9 sono tutte uguali in termini di difficolt\u00e0 e quindi intercambiabili.<\/p>\n<ul>\n<li>Il test \u00e8 disponibile al link seguente: <a href=\"https:\/\/wexnermedical.osu.edu\/brain-spine-neuro\/memory-disorders\/sage\/download-the-sage-test\" target=\"_blank\" rel=\"noopener\">https:\/\/wexnermedical.osu.edu\/brain-spine-neuro\/memory-disorders\/sage\/download-the-sage-test<\/a><\/li>\n<li>Istruzioni per calcolare il punteggio del test: <a href=\"https:\/\/wexnermedical.osu.edu\/-\/media\/files\/wexnermedical\/patient-care\/healthcare-services\/brain-spine-neuro\/memory-disorders\/sage\/italian\/sage_scoringinstructions_ita_2021.pdf?rev=583f63d342924294a2d9d61e304ad11a&amp;hash=2F5637E07CF8EA681AB69711A7DD1124\" target=\"_blank\" rel=\"noopener\">https:\/\/wexnermedical.osu.edu\/-\/media\/files\/wexnermedical\/patient-care\/healthcare-services\/brain-spine-neuro\/memory-disorders\/sage\/italian\/sage_scoringinstructions_ita_2021.pdf?rev=583f63d342924294a2d9d61e304ad11a&amp;hash=2F5637E07CF8EA681AB69711A7DD1124<\/a><\/li>\n<li>Spiegazioni sul punteggio ottenuto: <a href=\"https:\/\/wexnermedical.osu.edu\/-\/media\/files\/wexnermedical\/patient-care\/healthcare-services\/brain-spine-neuro\/memory-disorders\/sage\/italian\/sage_infosheet_ita_2021.pdf?rev=5e3b341174b04db5a102446c5313d10d&amp;hash=693A8BDC261779A678776E86A0F01578\" target=\"_blank\" rel=\"noopener\">https:\/\/wexnermedical.osu.edu\/-\/media\/files\/wexnermedical\/patient-care\/healthcare-services\/brain-spine-neuro\/memory-disorders\/sage\/italian\/sage_infosheet_ita_2021.pdf?rev=5e3b341174b04db5a102446c5313d10d&amp;hash=693A8BDC261779A678776E86A0F01578<\/a><\/li>\n<\/ul>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-text fusion-text-11\"><p>[1] Manafikhi R, Haik MB, Lahdo R, AlQuobaili F. Plasma amyloid \u03b2 levels in Alzheimer&#8217;s disease and cognitively normal controls in Syrian population. Med J Islam Repub Iran. 2021 Feb 8;35:19<\/p>\n<p>[2] Andrade-Guerrero J, Santiago-Balmaseda A, Jeronimo-Aguilar P, Vargas-Rodr\u00edguez I, Cadena-Su\u00e1rez AR, S\u00e1nchez-Garibay C, Pozo-Molina G, M\u00e9ndez-Catal\u00e1 CF, Cardenas-Aguayo MD, Diaz-Cintra S, Pacheco-Herrero M, Luna-Mu\u00f1oz J, Soto-Rojas LO. Alzheimer&#8217;s Disease: An Updated Overview of Its Genetics. Int J Mol Sci. 2023 Feb 13;24(4):3754<\/p>\n<p>[3] A Armstrong R. Risk factors for Alzheimer&#8217;s disease. Folia Neuropathol. 2019;57(2):87-105<\/p>\n<p>[4] Teipel S, Gustafson D, Ossenkoppele R, Hansson O, Babiloni C, Wagner M, Riedel-Heller SG, Kilimann I, Tang Y. Alzheimer Disease: Standard of Diagnosis, Treatment, Care, and Prevention. J Nucl Med. 2022 Jul;63(7):981-985<\/p>\n<p>[5] https:\/\/wexnermedical.osu.edu\/brain-spine-neuro\/memory-disorders\/sage<\/p>\n<\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-6 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-equal-height-columns\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:0px;--awb-padding-right:10%;--awb-padding-bottom:50px;--awb-padding-left:10%;--awb-background-color:rgba(139,195,74,0);--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-9 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last fusion-column-no-min-height\" style=\"--awb-bg-size:cover;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-column-content-centered\"><div class=\"fusion-column-content\"><div class=\"fusion-text fusion-text-12\"><h2 style=\"text-align: center;\">OMOMIND \u00e8 un integratore alimentare a base di Omotaurina, Betaina, Vitamina B6, Quatrefolic, Vitamina B12 e Vitamina D3. Utile nel rallentare il declino cognitivo e gli stadi iniziali di demenza.<\/h2>\n<\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-10 fusion_builder_column_3_4 3_4 fusion-three-fourth fusion-column-first\" style=\"--awb-padding-top:50px;--awb-bg-size:cover;width:75%;width:calc(75% - ( ( 4% ) * 0.75 ) );margin-right: 4%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-column-content-centered\"><div class=\"fusion-column-content\"><div class=\"fusion-text fusion-text-13\"><h2 class=\"fusion-responsive-typography-calculated\" style=\"text-align: left;\" data-fontsize=\"40\" data-lineheight=\"48px\">Si consiglia di assumere una bustina al giorno, dopo i pasti, da sciogliere in acqua.<\/h2>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:20px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><ul style=\"--awb-line-height:27.2px;--awb-icon-width:27.2px;--awb-icon-height:27.2px;--awb-icon-margin:11.2px;--awb-content-margin:38.4px;--awb-circlecolor:#9ca0a4;--awb-circle-yes-font-size:14.08px;\" class=\"fusion-checklist fusion-checklist-1 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-puzzle-piece fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">\n<div class=\"fusion-li-item-content\">\n<p><strong><span class=\"s2\">Non contiene glutine<\/span><\/strong><\/p>\n<\/div>\n<\/div><\/li><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-puzzle-piece fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">\n<div class=\"fusion-li-item-content\">\n<p><strong><span class=\"s2\">Non contiene lattosio<\/span><\/strong><\/p>\n<\/div>\n<\/div><\/li><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-puzzle-piece fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">\n<div class=\"fusion-li-item-content\">\n<p><strong><span class=\"s2\">Nessuna interazione farmacologica<\/span><\/strong><\/p>\n<\/div>\n<\/div><\/li><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-puzzle-piece fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">\n<div class=\"fusion-li-item-content\">\n<p><strong><span class=\"s2\">Efficace sia in monoterapia che in associazione<\/span><\/strong><\/p>\n<\/div>\n<\/div><\/li><\/ul><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-11 fusion_builder_column_1_4 1_4 fusion-one-fourth fusion-column-last\" style=\"--awb-padding-top:50px;--awb-bg-size:cover;width:25%;width:calc(25% - ( ( 4% ) * 0.25 ) );\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-column-content-centered\"><div class=\"fusion-column-content\"><div class=\"fusion-image-element fusion-image-align-center in-legacy-container\" style=\"text-align:center;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><div class=\"imageframe-align-center\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"1211\" height=\"1000\" title=\"OMOMIND_Comp_DX\" src=\"https:\/\/www.arcapharma.com\/web\/wp-content\/uploads\/2024\/04\/OMOMIND_Comp_DX.png\" alt class=\"img-responsive wp-image-7598\" srcset=\"https:\/\/www.arcapharma.com\/web\/wp-content\/uploads\/2024\/04\/OMOMIND_Comp_DX-200x165.png 200w, https:\/\/www.arcapharma.com\/web\/wp-content\/uploads\/2024\/04\/OMOMIND_Comp_DX-400x330.png 400w, https:\/\/www.arcapharma.com\/web\/wp-content\/uploads\/2024\/04\/OMOMIND_Comp_DX-600x495.png 600w, https:\/\/www.arcapharma.com\/web\/wp-content\/uploads\/2024\/04\/OMOMIND_Comp_DX-800x661.png 800w, https:\/\/www.arcapharma.com\/web\/wp-content\/uploads\/2024\/04\/OMOMIND_Comp_DX-1200x991.png 1200w, https:\/\/www.arcapharma.com\/web\/wp-content\/uploads\/2024\/04\/OMOMIND_Comp_DX.png 1211w\" sizes=\"(max-width: 800px) 100vw, 400px\" \/><\/span><\/div><\/div><div class=\"fusion-text fusion-text-14\"><p style=\"text-align: right;\"><span style=\"color: #283464;\"><strong>Gluten Free<\/strong><\/span><\/p>\n<\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-7 has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-equal-height-columns\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:75px;--awb-padding-right:10%;--awb-padding-bottom:75px;--awb-padding-left:10%;--awb-background-image:linear-gradient(180deg, #e8f1de 0%,#c0dcab 100%);--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-12 fusion_builder_column_1_4 1_4 fusion-one-fourth fusion-column-first\" style=\"--awb-padding-top:25px;--awb-padding-right:10%;--awb-padding-bottom:25px;--awb-padding-left:10%;--awb-bg-size:cover;width:25%;width:calc(25% - ( ( 4% ) * 0.25 ) );margin-right: 4%;\" data-motion-effects=\"[{&quot;type&quot;:&quot;&quot;,&quot;scroll_type&quot;:&quot;transition&quot;,&quot;scroll_direction&quot;:&quot;up&quot;,&quot;transition_speed&quot;:&quot;1&quot;,&quot;fade_type&quot;:&quot;in&quot;,&quot;scale_type&quot;:&quot;up&quot;,&quot;initial_scale&quot;:&quot;1&quot;,&quot;max_scale&quot;:&quot;1.5&quot;,&quot;min_scale&quot;:&quot;0.5&quot;,&quot;initial_rotate&quot;:&quot;0&quot;,&quot;end_rotate&quot;:&quot;30&quot;,&quot;initial_blur&quot;:&quot;0&quot;,&quot;end_blur&quot;:&quot;3&quot;,&quot;start_element&quot;:&quot;top&quot;,&quot;start_viewport&quot;:&quot;bottom&quot;,&quot;end_element&quot;:&quot;bottom&quot;,&quot;end_viewport&quot;:&quot;top&quot;,&quot;mouse_effect&quot;:&quot;track&quot;,&quot;mouse_effect_direction&quot;:&quot;opposite&quot;,&quot;mouse_effect_speed&quot;:&quot;2&quot;,&quot;infinite_animation&quot;:&quot;float&quot;,&quot;infinite_animation_speed&quot;:&quot;2&quot;}]\" data-scroll-devices=\"small-visibility,medium-visibility,large-visibility\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-column-content-centered\"><div class=\"fusion-column-content\"><div class=\"fusion-image-element in-legacy-container\" style=\"--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-none imageframe-2 hover-type-none\"><img decoding=\"async\" width=\"769\" height=\"366\" title=\"Logo_OMOMIND\" src=\"https:\/\/www.arcapharma.com\/web\/wp-content\/uploads\/2024\/03\/Logo_OMOMIND.png\" alt class=\"img-responsive wp-image-7432\" srcset=\"https:\/\/www.arcapharma.com\/web\/wp-content\/uploads\/2024\/03\/Logo_OMOMIND-200x95.png 200w, https:\/\/www.arcapharma.com\/web\/wp-content\/uploads\/2024\/03\/Logo_OMOMIND-400x190.png 400w, https:\/\/www.arcapharma.com\/web\/wp-content\/uploads\/2024\/03\/Logo_OMOMIND-600x286.png 600w, https:\/\/www.arcapharma.com\/web\/wp-content\/uploads\/2024\/03\/Logo_OMOMIND.png 769w\" sizes=\"(max-width: 800px) 100vw, 400px\" \/><\/span><\/div><div class=\"fusion-text fusion-text-15\"><p style=\"text-align: center;\"><span style=\"color: #ffffff;\"><strong>Gluten Free<\/strong><\/span><\/p>\n<\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-13 fusion_builder_column_3_4 3_4 fusion-three-fourth fusion-column-last\" style=\"--awb-padding-top:25px;--awb-padding-right:10%;--awb-padding-bottom:25px;--awb-padding-left:10%;--awb-bg-size:cover;width:75%;width:calc(75% - ( ( 4% ) * 0.75 ) );\" data-motion-effects=\"[{&quot;type&quot;:&quot;&quot;,&quot;scroll_type&quot;:&quot;transition&quot;,&quot;scroll_direction&quot;:&quot;up&quot;,&quot;transition_speed&quot;:&quot;1&quot;,&quot;fade_type&quot;:&quot;in&quot;,&quot;scale_type&quot;:&quot;up&quot;,&quot;initial_scale&quot;:&quot;1&quot;,&quot;max_scale&quot;:&quot;1.5&quot;,&quot;min_scale&quot;:&quot;0.5&quot;,&quot;initial_rotate&quot;:&quot;0&quot;,&quot;end_rotate&quot;:&quot;30&quot;,&quot;initial_blur&quot;:&quot;0&quot;,&quot;end_blur&quot;:&quot;3&quot;,&quot;start_element&quot;:&quot;top&quot;,&quot;start_viewport&quot;:&quot;bottom&quot;,&quot;end_element&quot;:&quot;bottom&quot;,&quot;end_viewport&quot;:&quot;top&quot;,&quot;mouse_effect&quot;:&quot;track&quot;,&quot;mouse_effect_direction&quot;:&quot;opposite&quot;,&quot;mouse_effect_speed&quot;:&quot;2&quot;,&quot;infinite_animation&quot;:&quot;float&quot;,&quot;infinite_animation_speed&quot;:&quot;2&quot;}]\" data-scroll-devices=\"small-visibility,medium-visibility,large-visibility\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-column-content-centered\"><div class=\"fusion-column-content\"><div class=\"fusion-text fusion-text-16\"><p class=\"p1\" style=\"text-align: center;\"><span style=\"color: #0a734b;\">In Farmacia, Parafarmacia e sul nostro Negozio on-line<\/span><\/p>\n<\/div><div class=\"fusion-aligncenter\"><a class=\"fusion-button button-flat button-large button-custom fusion-button-default button-1 fusion-button-default-span fusion-button-default-type\" style=\"--button_accent_color:#0a734b;--button_border_color:#0a734b;--button_accent_hover_color:#ffffff;--button_border_hover_color:#0a734b;--button_border_width-top:3px;--button_border_width-right:3px;--button_border_width-bottom:3px;--button_border_width-left:3px;--button_gradient_top_color:#ffffff;--button_gradient_bottom_color:#ffffff;--button_gradient_top_color_hover:#0a734b;--button_gradient_bottom_color_hover:#0a734b;\" target=\"_self\" href=\"https:\/\/www.arcapharma.com\/web\/prodotto\/omomind\/\"><span class=\"fusion-button-text\">Acquista on-line<\/span><\/a><\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":7646,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-7641","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-categorizzato"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.8 (Yoast SEO v28.6) - 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